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Famous for a reason! This slow cooker Mississippi Pot Roast is unbelievably tender and packed with a savory, tangy flavor. With just five main ingredients and minimal prep, it's the ultimate set-it-and-forget-it comfort food that creates its own rich, delicious gravy.
Prepare and Sear the Roast (10-12 minutes)
Add Seasonings and Toppings (3 minutes)
Slow Cook to Perfection (8-10 hours)

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Famous for a reason! This slow cooker Mississippi Pot Roast is unbelievably tender and packed with a savory, tangy flavor. With just five main ingredients and minimal prep, it's the ultimate set-it-and-forget-it comfort food that creates its own rich, delicious gravy.
This southern recipe takes 495 minutes to prepare and yields 6 servings. At 873.64 calories per serving with 52.52g of protein, it's a beginner-friendly recipe perfect for dinner or supper or lunch.
Shred and Serve (10-15 minutes)
Use hot pepperoncini peppers or add 1/2 teaspoon of red pepper flakes along with the other seasonings for an extra kick.
Beef brisket or a bottom round roast can be used instead of chuck roast. Cooking times may need to be adjusted slightly.
For a one-pot meal, add 1 lb of baby carrots and 1 large, quartered onion to the bottom of the slow cooker before adding the seared roast.
Sear the roast in the Instant Pot on 'Sauté' mode. Add remaining ingredients, seal, and cook on high pressure for 60-70 minutes. Allow a 15-minute natural release before serving.
Beef is a complete protein, providing all the essential amino acids your body needs for muscle repair, tissue growth, and maintaining a healthy immune system.
This dish provides heme iron from the beef, a form of iron that is more easily absorbed by the body than plant-based iron. Iron is crucial for forming hemoglobin, which transports oxygen and helps prevent fatigue.
Beef is a natural source of several B vitamins, particularly B12, niacin, and B6. These vitamins are vital for converting food into energy, supporting brain function, and maintaining a healthy nervous system.
Mississippi Pot Roast is a rich, indulgent comfort food. While it is high in protein, it is also high in sodium and saturated fat from the butter and seasoning packets. It's best enjoyed in moderation. To make it healthier, you can use low-sodium seasoning packets or use half the amount of butter.
A typical serving (approximately 1 cup or 310g) of Mississippi Pot Roast contains around 450-550 calories. The exact amount can vary depending on the fat content of the beef and the specific brands of ingredients used.
The recipe is widely credited to Robin Chapman, a resident of Ripley, Mississippi, from the 1990s. She adapted a family recipe, and its popularity grew through church cookbooks and online forums, eventually earning its geographical name.
While you can technically skip searing, it is highly recommended. Searing creates a deep, brown crust through the Maillard reaction, which adds a significant layer of rich, savory flavor to both the meat and the gravy that you can't achieve otherwise.
No, the whole pepperoncini peppers add a mild, tangy, and slightly briny flavor rather than intense heat. The long, slow cooking process mellows them out considerably. They contribute a unique tang that balances the richness of the butter and beef.
Yes, while chuck roast is ideal for its marbling and tenderness, you can also use a bottom round roast or beef brisket. Be aware that leaner cuts may not be as fall-apart tender and cooking times might need slight adjustments.